The information on this website is for educational purposes only. Do not act or rely upon the information on this website without seeking independent professional medical advice.  Prolotherapy is a medical technique. As with any medical technique, results will vary among individuals, and there is no guarantee that you will receive the same outcome as patient reports here. Prolotherapy injections may not work for you and as with all medical procedures there are risks involved. These risks should be discussed with a qualified health care professional prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

Osteoarthritis


Comparison of platelet-r​ich plasma formulatio​ns for cartilage healing: an in vitro study. (2014)
Read about the different kinds of platelet-rich plasma formulations and which formulation is best suited for the treatment of degenerative joint diseases.

Biology of platelet-r​ich plasma and its clinical application in cartilage repair. (2014)
This article Reviews the physiological concepts of how platelet-rich plasma therapy can aid in cartilage repair and improve joint function.

Dextrose Prolotherapy for Knee Osteoarthritis:  A Randomized Controlled Trial (2013) 
This triple blinded study showed clinically meaningful sustained improvement of pain, function and stiffness scores for patients with knee osteoarthritis when treated with Dextrose Prolotherapy.


The effect of platelet-rich plasma on pain, function, and quality of life of patients with knee osteoarthritis. (2013)
This study showed that intra-articular knee injection of PRP can decrease joint pain and stiffness and improve patients’ quality of living in short term.  

Dextrose Prolotherapy for Knee Osteoarthritis, a Randomized Controlled Trial. (2013)
Prolotherapy resulted in clinically meaningful sustained improvement of pain, function, and stiffness scores for knee osteoarthritis compared with blinded saline injections and at-home exercises.

Clinical and MRI Outcomes After Platelet-Rich Plasma Treatment for Knee Osteoarthritis. (2013)
This case report shows how platelet-rich plasma therapy can have a positive outcome in patients suffering from early onset Osteoarthritis of the knee.

Treatment With PRP is More Effective Than Placebo for Knee Osteoarthritis, a Prospective, Double-blind, Randomized Trial. (2013)
The groups treated with PRP (both, single injection or 2 injections) had better results than did the group injected with saline only.

Mesenchymal stem cell-based treatment for cartilage defects in osteoarthritis. (2012)
This article summarizes the current knowledge about Mesenchymal stem cell-based therapy for prevention or treatment of osteoarthritis in animal models and in clinical applications as well as potential future strategies for osteoarthritis treatment.

Infrapatellar Fat Pad-derived Mesenchymal Stem Cell Therapy for Knee Osteoarthritis. (2012)
The short-term results of the study show that infrapatellar fat pad derived mesenchymal stem cell therapy with intra-articular injections is safe, and provides assistance in reducing pain and improving function in patients with knee osteoarthritis.

Intra-articular injection of autologous mesenchymal stem cells in six patients with knee osteoarthritis. (2012)
This study shows satisfactory effects of intra-articular injection of mesenchymal stem cells in 6 patients with knee osteoarthritis.  

Regenerati​ve Injection Therapy for Osteoarthr​itis: Fundamenta​l Concepts and Evidence-B​ased Review. (2012)
Learn about regenerative injection therapy and how it might stimulate collagen deposition to improve pain and joint functionality in those suffering from Osteoarthritis.

Platelet Rich Plasma Intraarticular Joint Injections for the Treatment of Degenerative Cartilage Lesions and Osteoarthritis. (2012)
Improvement in pain and function was noted in patients with degenerative knee lesions 24 months after treatment as compared to prior to any treatment.  

Effect of Autologous Platelet Rich Plasma Releasate on Intervertebral Disc Degeneration in the Rabbit Anular Puncture Model: A Preclinical Study. (2012)
The administration of platelet-rich plasma increased the number of cartilage cells and disc height in back arthritis in this animal model.  

Effect of Regenerative Injection Therapy on Function and Pain in Patients with Knee Osteoarthrits: A Randomized Crossover Study. (2012)
Dextrose Prolotherapy used in knee osteoarthritis resulted in a marked reduction in symptoms. 

The Ligament Injury - Osteoarthritis Connection: The Role of Prolotherapy in Ligament Repair and the Prevention of Osteoarthritis. (2011)
This article reviews the physiology of ligaments and damage sustained due to injury, and how these changes trigger the development of osteoarthritis if ligament function is not restored.   

Advances in Regenerative Medicine: High-Density Platelet Rich Plasma and Stem Cell Prolotherapy for Musculoskeletal Pain. (2011)
This article summarizes how Biocellular Prolotherapy works to treat joint injuries and resolve musculoskeletal pain.

The New Age of Prolotherapy. (2010)
Discusses the advances that have been made in Prolotherapy including Platelet Rich Plasma, adult stem cell sources such as bone marrow and adipose, and the use of imaging with musculoskeletal ultrasound to increase precision in diagnosis and treatment. 

Injection of Platelet Rich Plasma in Patients with Primary and Secondary Knee Osteoarthritis: A Pilot Study.  (2010)
This study demonstrated significant and almost linear improvements in pain and symptom relief after PRP Prolotherapy treatments.  The majority of the patients expressed a favorable outcome at 12 months after treatment.

The Regeneration of Articular Cartilage with Prolotherapy. (2009)
In this medical editorial the author makes the case for using Prolotherapy as the treatment of choice for degenerated and arthritic joints.

Randomized, Prospective, Placebo-Controlled Double-Blind Study of Dextrose Prolotherapy for Osteoarthritic Thumb and Finger (DIP, PIP and Trapeziometacarpal Joints: Evidence of Clinical Efficacy. (2000)
Prolotherapy was shown to be clinically effective and safe, reducing pain and increasing mobility, in patients with thumb and finger pain.  


Randomized Prospective Double-Blind Placebo-Controlled Study of Dextrose Prolothereapy for Knee Osteoarthritis With or Without ACL Laxity. (2000)
Dextrose Prolotherapy injection of 38 knees resulted in a clinically significant and statistically significant improvement in knee osteoarthritis.