The information on this website is for educational purposes only. Do not act or rely upon the information on this website without seeking independent professional medical advice.  Prolotherapy is a medical technique. As with any medical technique, results will vary among individuals, and there is no guarantee that you will receive the same outcome as patient reports here. Prolotherapy injections may not work for you and as with all medical procedures there are risks involved. These risks should be discussed with a qualified health care professional prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.


Dextrose Prolotherapy is the original form of Prolotherapy originating in the 1930’s.  Concentrated dextrose (sugar water) or saline (salt water) or other natural substances, are used as an irritant to stimulate a mild inflammation which “tricks” the body into thinking the area is injured and to begin healing again.  Dextrose Prolotherapy raises growth factor levels or effectiveness to promote tissue repair, reducing or eliminating musculoskeletal pain.  

Dextrose Prolotherapy is practiced by physicians in the U.S. and worldwide, has been shown effective in treating many musculoskeletal conditions - such as tendinopathies, ligament sprains, back and neck pain, tennis/golfers elbow, ankle pain, joint laxity and instability, plantar fasciitis, shoulder, knee pain and other joint pain.  It is commonly referred to as simply “Prolotherapy”.

How Prolotherapy Works

Prolotherapy works by causing a temporary, low grade inflammation at the injection site, activating fibroblasts to the area, which, in turn, synthesize precursors to mature collagen and thus reinforce connective tissue.  It has been well documented that direct exposure of fibroblasts to growth factors (either naturally occurring or added) causes new cell growth and collagen deposition.  Inflammation creates secondary growth factor elevation. The inflammatory stimulus of Prolotherapy raises the level of growth factors to resume or initiate a new connective tissue repair sequence which had prematurely aborted or never started.  Animal biopsy studies show ligament thickening, enlargement of the tendinosseous junction, and strengthening of the tendon or ligament after Prolotherapy injections.

Prolotherapy for Musculoskeletal Pain.  

Practical Pain Management, January/February 2007.  

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