The information on this website is for educational purposes only. Do not act or rely upon the information on this website without seeking independent professional medical advice.  Prolotherapy is a medical technique. As with any medical technique, results will vary among individuals, and there is no guarantee that you will receive the same outcome as patient reports here. Prolotherapy injections may not work for you and as with all medical procedures there are risks involved. These risks should be discussed with a qualified health care professional prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

Degenerative Joint Disease


Effect of Regenerative Injection Therapy on Function and Pain in Patients with Knee Osteoarthrits: A Randomized Crossover Study. (2012)
Dextrose Prolotherapy used in knee osteoarthritis resulted in a marked reduction in symptoms. 

Angiogenic and Osteogenic Potential of Platelet Rich Plasma and Adipose Derived Stem Cell Laden Alginate Microsheres. (2012)
This paper expores the evidence for use of a mixture of platelet-rich plasma and adipose-derived stem cells in regerative medicine.

Use of Platelet Rich Plasma in the Treatment of Bisphosphonate Related Osteonecrosis of the Jaw. (2012)
This paper describes the results of using platelet-rich plasma in the management of bisphosphonate-associated necrosis of the jaw. 

Regenerative Injection Therapy with Whole Bone Marrow Aspirate for Degenerative Joint Disease:  A Case Series (2012)
Seven patients in this case series received whole bone marrow injections for osteoarthritic joints, and all reported improvements with respect to pain, functionality, and quality of life.

Stem Cell Prolotherapy in Regenerative Medicine: Theory, Background and Protocols. (2011)
This is the first published protocol on "Biocellular Prolotherapy": the use of either bone marrow or fat (adipose) as a repair/stem cell source to maximize healing in Prolotherapy. Includes case reports and ultrasound images demonstrating improvement before and after treatment.  

Advances in Regenerative Medicine: High-Density Platelet Rich Plasma and Stem Cell Prolotherapy for Musculoskeletal Pain. (2011)
This article summarizes how Biocellular Prolotherapy  works to resolve musculoskeletal pain. 

The New Age of Prolotherapy. (2010)
Discusses the advances that have been made in Prolotherapy including Platelet Rich Plasma, adult stem cell sources such as bone marrow and adipose, and the use of imaging with musculoskeletal ultrasound to increase precision in diagnosis and treatment.

The Regeneration of Articular Cartilage with Prolotherapy. (2009)
In this medical editorial the author makes the case for using Prolotherapy as the treatment of choice for degenerated and arthritic joints. 

Platelet Rich Plasma (PRP) Matrix Grafts. (2008)
Application of platelet rich plasma to musculoskeletal medicine and the science behind it are discussed.