The information on this website is for educational purposes only. Do not act or rely upon the information on this website without seeking independent professional medical advice.  Prolotherapy is a medical technique. As with any medical technique, results will vary among individuals, and there is no guarantee that you will receive the same outcome as patient reports here. Prolotherapy injections may not work for you and as with all medical procedures there are risks involved. These risks should be discussed with a qualified health care professional prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

Arthritis

Dextrose Prolotherapy for Knee Osteoarthritis:  A Randomized Controlled Trial (2013) 
This triple blinded study showed clinically meaningful sustained improvement of pain, function and stiffness scores for patients with knee osteoarthritis when treated with Dextrose Prolotherapy.

Effect of Regenerative Injection Therapy on Function and Pain in Patients with Knee Osteoarthrits: A Randomized Crossover Study. (2012)
Dextrose Prolotherapy used in knee osteoarthritis resulted in a marked reduction in symptoms.

Effect of Autologous Platelet - Rich - Plasma - Releasate on Intervertebral Disc Degeneration in the Rabbit Anular Puncture Model: A Preclinical Study. (2012)
The administration of platelet-rich plasma increased the number of cartilage cells and disc height in back arthritis in this animal model.

Comparative Evaluation of Mesenchymal Stem Cells From Bone Marrow and Adipose Tissue Seeded in PRP Derived Scaffold for Cartilage Regeneration (2012)
The study findings suggest that PRP is a candidate bioactive scaffold capable of releasing endogenous growth factors and that bone marrow stem cell and adipose derived stem cell seeded within the PRP scaffold differentiate into chondrocytes and may be suitable for cell-based cartilage repair.

The Effect of Platelet Rich Plasma on the Regenerative Therapy of Muscle Derived Stem Cell for Articular Cartilage Repair (2012)
This study indicates that the addition of PRP to muscle derived stem cells significantly improved articular cartilage repair.  

Intraarticular Injection of Platelet-Rich Plasma Reduces Inflammation in a Pig Model in Rheumatoid Arthritis of the Knee Joint. (2011)
PRP was effective in reducing joint destruction caused by rheumatoid arthritis in an animal model. 

The Ligament Injury - Osteoarthritis Connection: The Role of Prolotherapy in Ligament Repair and the Prevention of Osteoarthritis. (2011)
This article reviews the scientific literature and discusses the relationship between Prolotherapy, ligagment repair, and the prevention of arthritis. 

Advances in Regenerative Medicine: High-Density Platelet Rich Plasma and Stem Cell Prolotherapy for Musculoskeletal Pain. (2011)
This article summarizes how Biocellular Prolotherapy  works to stimulate repair of injured joints.

The Regeneration of Articular Cartilage with Prolotherapy. (2009)
In this medical editorial the author makes the case for using Prolotherapy as the treatment of choice for degenerated and arthritic joints.