The information on this website is for educational purposes only. Do not act or rely upon the information on this website without seeking independent professional medical advice.  Prolotherapy is a medical technique. As with any medical technique, results will vary among individuals, and there is no guarantee that you will receive the same outcome as patient reports here. Prolotherapy injections may not work for you and as with all medical procedures there are risks involved. These risks should be discussed with a qualified health care professional prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

Ankle Sprain or Tear


Platelet-Rich Plasma or Hyaluronate in the Management of Osteochrondral Lesions of the Talus. (2012)
Injection of platelet-rich plasma in ankle cartilage lesions resulted in a significantly better outcome than injection of hyaluronate, with decrease in pain scores and increase in function.

The Use of Platelet-Rich Plasma in the Management of Foot and Ankle Conditions. (2011)
This article discusses use of Platelet Rich Plasma and Bone Marrow Aspirate in 684 patients with lower extremity injuries and pain, and concludes that healing is more complete and rapid when used.  

Platelet-Rich Plasma: More than a last resort? (2011)
This review article discusses the PRP controversy and concludes it appears to have great value in the healing of lower extremity injuries.

Dextrose Prolotherapy Injections for Chronic Ankle Pain. (2010)
In this observational study improvement was noted in patients treated for ankle pain with dextrose Prolotherapy, resulting in less pain, stiffness, increased range of motion, more activity and less need for medication.  

High Resolution Ultrasound and Magnetic Resonance Imaging to Document Tissue Repair After Prolotherapy. (2006)
A Report of Three Cases (including Ankle). A near thickness tear of the Anterior Talofibular Ligament and Deltoid ligaments in the ankle are documented resolved with dextrose Prolotherapy.  At patient follow up a year and a half later patient states "full speed" without weakness, pain or instability.